Increased breast cancer risk in women with neurofibromatosis type 1: a meta-analysis and systematic review of the literature.
Lorena P Suarez-KellyLianbo YuDavid KlineEric B SchneiderDoreen M AgneseWilliam E CarsonPublished in: Hereditary cancer in clinical practice (2019)
This systematic literature review and meta-analysis suggests that women with NF1 < 50 y.o. have a five-fold increased risk of BC, present with more advanced disease, and may have an increased BC related mortality. Increased awareness and implementation of recent National Comprehensive Cancer Network early BC screening guidelines for this high-risk patient population is essential. Additional evaluation on the influence of NF1 gene mutations identified in patients undergoing hereditary cancer genetic testing on breast cancer risk in individuals without clinical evidence of NF1 is needed.
Keyphrases
- breast cancer risk
- signaling pathway
- papillary thyroid
- lps induced
- patients undergoing
- case report
- pi k akt
- oxidative stress
- squamous cell
- nuclear factor
- healthcare
- primary care
- inflammatory response
- cardiovascular disease
- type diabetes
- risk factors
- lymph node metastasis
- immune response
- squamous cell carcinoma
- coronary artery disease
- young adults
- clinical practice