Effects of melatonin on insulin signaling and inflammatory pathways of rats with apical periodontitis.
B S TavaresThaís Verônica Saori TsosuraMaria Sara de Lima Coutinho MatteraJ O SantelliBianca Elvira BelardiFernando Yamamoto ChibaLuciano Tavares Angelo CintraCristiane Cantiga da SilvaDóris Hissako MatsushitaPublished in: International endodontic journal (2021)
Melatonin is a potent adjuvant treatment for improving apical periodontitis-associated changes in insulin sensitivity, insulin signalling and inflammatory pathways. In addition, the negative impact of AP on general health was also demonstrated.