Epigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance.

Ping ZhangHarindra E AmarasingheJustin P WhalleyChwen TayHai FangGabriele MiglioriniAndrew C BrownAlice AllcockGiuseppe ScozzafavaPhalguni RathBenjamin DaviesJulian C Knight

Published in: Genome biology (2022)

Our study demonstrates the importance of context-specific macrophage enhancers in gene regulation and utility for interpreting disease associations, providing a roadmap to link genetic variants with molecular and cellular functions.

Keyphrases

innate immune
adipose tissue
transcription factor
binding protein
single molecule