Role of CD19 + CD5 + CD1d + Bregs in maintaining the Th17/Treg balance in mice with systemic lupus erythematosus complicated with atherosclerosis.

Zhen-Zhen ZhuXiao-Huan ChenSi-Ru WeiJia XuYa-Hui WangWen-Jue WuHong LiuHan-You Mo

Published in: International journal of rheumatic diseases (2023)

The proportion of Breg decreases was negatively associated with increased Th17/Treg which was increased in SLE + AS mice, indicating that Bregs may regulate Th17/Treg cell homeostasis and cytokine release via IL-35 and TGF-β production.

Keyphrases

systemic lupus erythematosus
high fat diet induced
disease activity
single cell
cardiovascular disease
cell therapy
transforming growth factor
stem cells
metabolic syndrome
rheumatoid arthritis
mesenchymal stem cells
wild type
bone marrow
signaling pathway
insulin resistance