MRP14 enhances the ability of macrophage to recruit T cells and promotes obesity-induced insulin resistance.

Chang XiaMichael RazaviXiaoquan RaoZachary BraunsteinHong MaoAmelia C ToomeyYunmei WangDaniel I SimonShi ZhaoSanjay RajagopalanJixin Zhong

Published in: International journal of obesity (2005) (2019)

Our data indicate that MRP14 deficiency decreases obesity-induced insulin resistance and MRP8/14 regulates T-cell recruitment through the induction of T-cell chemoattractant production from macrophages.

Keyphrases

insulin resistance
adipose tissue
metabolic syndrome
high fat diet induced
type diabetes
high fat diet
skeletal muscle
polycystic ovary syndrome
high glucose
diabetic rats
weight loss
drug induced
weight gain
oxidative stress
machine learning
physical activity
big data
deep learning
data analysis