PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Triggers Vascular Smooth Muscle Cell Senescence and Apoptosis: Implication of Its Direct Role in Degenerative Vascular Disease.
Yanan GuoZhihan TangBinjie YanHao YinShi TaiJuan PengYuting CuiYu GuiDarrell BelkeShenghua ZhouXi-Long ZhengPublished in: Arteriosclerosis, thrombosis, and vascular biology (2021)
Our findings demonstrate that PCSK9 inhibits proliferation and induces polyploidization, senescence, and apoptosis, which may be relevant to various degenerative vascular diseases.