Effects of Alcohol and Estrogen Receptor Blockade Using ICI 182,780 on Bone in Ovariectomized Rats.
Lindsay WagnerKathy HoweKenneth A PhilbrickGianni F MaddalozzoAmida F KuahCarmen P WongDawn A OlsonAdam J BranscumUrszula T IwaniecRussell T TurnerPublished in: Alcoholism, clinical and experimental research (2019)
Alcohol exaggerated bone loss in ovx rats in the presence or absence of estrogen receptor blockade with ICI. The negligible effect of alcohol on uterus and limited effects of ICI on bone in alcohol-fed ovx rats suggest that estrogen receptor signaling plays a limited role in the action of alcohol on bone in a rat model for chronic alcohol abuse.