Wogonin Alleviates Kidney Tubular Epithelial Injury in Diabetic Nephropathy by Inhibiting PI3K/Akt/NF-κB Signaling Pathways.

Lei LeiJing ZhaoXue-Qi LiuJuan ChenXiang-Ming QiLing-Ling XiaYong-Gui Wu

Published in: Drug design, development and therapy (2021)

Our study is the first to demonstrate the novel role of wogonin in mitigating tubulointerstitial fibrosis and renal tubular cell injury via regulating PI3K/Akt/NF-κB signaling pathway-mediated autophagy and inflammation. Wogonin might be a latent remedial drug against tubular epithelial injury in DN by targeting PI3K.

Keyphrases

signaling pathway
pi k akt
diabetic nephropathy
cell cycle arrest
induced apoptosis
epithelial mesenchymal transition
oxidative stress
cell proliferation
high glucose
single cell
stem cells
cell therapy
cell death
endothelial cells
endoplasmic reticulum stress
adverse drug
drug induced
toll like receptor