Reprogramming adipose mesenchymal stem cells into islet β-cells for the treatment of canine diabetes mellitus.

Pengxiu DaiGuixiang QiHaojie XuMingde ZhuJiakai LiYijing ChenLuwen ZhangXinke ZhangYihua Zhang

Published in: Stem cell research & therapy (2022)

The aMSCs were efficiently reprogrammed into ra-βCs using a six-gene combination. The cotransplantation of ra-βCs and aMSCs as a treatment for canine diabetes is feasible, which provides a theoretical basis and therapeutic method for the treatment of canine diabetes.

Keyphrases

mesenchymal stem cells
type diabetes
cardiovascular disease
rheumatoid arthritis
induced apoptosis
adipose tissue
genome wide
gene expression
systemic lupus erythematosus
ankylosing spondylitis
cell death
endoplasmic reticulum stress
weight loss
transcription factor
cell cycle arrest