Disulfiram Reduces Atherosclerosis and Enhances Efferocytosis, Autophagy, and Atheroprotective Gut Microbiota in Hyperlipidemic Mice.

C Alicia TraughberKara TiminskiAshutosh PrinceNilam BhandariKalash NeupaneMariam R KhanEsther OpokuEmmanuel OpokuGregory BrubakerJunchul ShinJunyoung HongBabunageswararao Kanuri Elif Gulin Ertugral-Samgar Prabhakara R Nagareddy Chandrasekhar R Kothapalli Olga A Cherepanova Jonathan D Smith Kailash Gulshan

Published in: Journal of the American Heart Association (2024)

Taken together, our data show that disulfiram can simultaneously modulate several atheroprotective pathways in a GsdmD-dependent as well as GsdmD-independent manner.

Keyphrases

cell death
electronic health record
endoplasmic reticulum stress
high fat diet induced
cardiovascular disease
signaling pathway
oxidative stress
big data
wild type
adipose tissue