Homologous Recombination Deficiency and Cyclin E1 Amplification Are Correlated with Immune Cell Infiltration and Survival in High-Grade Serous Ovarian Cancer.
Lilian van WagensveldJuliette O A M van BaalMaite TimmermansDuco GaillardLauri BorghuisSeth B CoffeltEfraim H RosenbergChristianne A R LokHans W NijmanLoes F S KooremanJoyce SandersMarco de BruijnLodewyk F A WesselsRianne van der WielChristian RauschAnnegien BroeksRoy F P M KruitwagenMaaike A van der AaGabe S SonkePhilip C SchoutenKoen K van de VijverHugo M HorlingsPublished in: Cancers (2022)
Molecular profiles and TME are associated with OS. TME differs per profile, with higher immune cell densities showing a favorable OS, even within the profiles. HGSOC does not reflect one entity but comprises different entities based on molecular profiles and TME.