Rapid frequency-dependent changes in free mitochondrial calcium concentration in rat cardiac myocytes.

Rob C I WüstMichiel HelmesJody L MartinThomas J T van der WardtRené J P MustersJolanda van der VeldenGer J M Stienen

Published in: The Journal of physiology (2017)

rapid increases in [Ca2+ ]m allow for fast adjustment of mitochondrial ATP production to increases in myocardial demand on a beat-to-beat basis and mitochondrial calcium release depends on mNCE activity and mitochondrial calcium buffering.

Keyphrases

oxidative stress
left ventricular
protein kinase