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Electrical monitoring of human-serum-albumin-templated molecularly imprinted polymer nanoparticles with high affinity based on molecular charges and their visualization.

Youyuan ManShoichi NishitaniKazuaki SawadaToshiya Sakata
Published in: Chemical communications (Cambridge, England) (2024)
Human-serum-albumin (HSA)-templated molecularly imprinted polymer nanoparticles (nano-MIPs) were integrated with a solution-gated field-effect transistor-based biosensor. The real-time electrical analysis of nano-MIP-HSA binding showed a high affinity and specificity of nano-MIPs for HSA. Moreover, the binding behaviour was continuously visualised using a solution-gated complementary metal-oxide semiconductor array image biosensor.
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