Inaccurately Reported Statin Use Affects the Assessing of Lipid Profile Measures and Their Association with Coronary Artery Disease Risk.
Anna A IvanovaMichael S GardnerJennifer D KusovschiBryan A ParksDavid M SchieltzAkshay BarejaRobert W McGarrahWilliam E KrausZsuzsanna KuklenyikJames L PirkleJohn R BarrPublished in: Clinical chemistry (2024)
Our study uncovered prominent discrepancies between medication records and actual statin use measured by mass spectrometry. We showed that inaccurate statin use assessments may lead to overestimation and underestimation of LDL levels in statin user and nonuser categories, exaggerating the reverse epidemiology association between LDL levels and CAD diagnosis. Combining medication history and quantitative statin assay data can significantly improve the design, analysis, and interpretation of clinical and epidemiological studies.
Keyphrases
- coronary artery disease
- low density lipoprotein
- cardiovascular disease
- percutaneous coronary intervention
- mass spectrometry
- cardiovascular events
- coronary artery bypass grafting
- healthcare
- emergency department
- high throughput
- type diabetes
- heart failure
- risk factors
- big data
- acute coronary syndrome
- machine learning
- liquid chromatography
- high performance liquid chromatography
- atrial fibrillation
- deep learning
- single cell
- gas chromatography