Links Between Adipose Tissue Gene Expression of Gut Leakage Markers, Circulating Levels, Anthropometrics, and Diet in Patients with Coronary Artery Disease.
Susanne Kristine AuneRagnhild HelsethAre A KalstadKristian LaakeSissel ÅkraHarald ArnesenSvein SolheimIngebjørg SeljeflotPublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2024)
In patients with established CAD, circulating levels of LBP and gene expression of CD14 and TLR2 in SAT were related to obesity, MetS, T2DM, and hypertension. This suggests that the LPS-LBP-CD14 inflammatory axis is activated in the chronic low-grade inflammation associated with cardiometabolic abnormalities, whereas no significant associations with dietary habits were observed.
Keyphrases
- gene expression
- low grade
- adipose tissue
- high grade
- insulin resistance
- dna methylation
- weight loss
- oxidative stress
- inflammatory response
- blood pressure
- metabolic syndrome
- coronary artery disease
- type diabetes
- toll like receptor
- physical activity
- immune response
- nk cells
- skeletal muscle
- drug induced
- glycemic control
- nuclear factor