The liver-first approach for synchronous colorectal liver metastases: A systematic review and meta-analysis of completion rates and effects on survival.
Adam ZeyaraWilliam TorénKjetil SøreideRoland AnderssonPublished in: Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society (2021)
The liver-first approach offers a complete resection to most patients enrolled, with an overall survival benefit when completion can be assured. One-fifth fails to return to intended oncologic therapy and the major cause is interim metastatic progression, most often in the liver. Risk of non-completion is related to a higher number of lesions and large metastases. The majority of studies stem from primary rectal cancers, which may influence on the return to intended oncologic therapy as well.PROSPERO id no: 170459.
Keyphrases
- liver metastases
- end stage renal disease
- rectal cancer
- newly diagnosed
- ejection fraction
- squamous cell carcinoma
- chronic kidney disease
- small cell lung cancer
- prostate cancer
- peritoneal dialysis
- radical prostatectomy
- robot assisted
- prognostic factors
- patient reported outcomes
- stem cells
- mesenchymal stem cells
- young adults
- bone marrow
- case control