YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner.
Hengyu ChenYuanhang YuMing YangHaohao HuangShenghui MaJin HuZihan XiHui GuoGuojie YaoLiu YangXiaoqing HuangFeng ZhangGuanghong TanHuangfu WuWuping ZhengLei LiPublished in: Cell & bioscience (2022)
Our study reveals a novel YTHDF1/FOXM1 regulatory pathway that contributes to metastasis and progression of breast cancer, suggesting that YTHDF1 might be applied as a potential biomarker and therapeutic target. That also advances our understanding of the tumorigenesis for breast cancer from m6A epigenetic regulation.
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