Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance.

Nicholas L Fletcher A Prior O Choy James Humphries Pie Huda Saikat Ghosh Zachary H Houston Craig A Bell Kristofer J Thurecht

Published in: Chemical communications (Cambridge, England) (2022)

Pre-targeting of bispecific antibodies is probed to enhance tumour retention while limiting clearance of administered multifunctional branched PEGylated nanomedicines. The temporal influence of pre-targeting on polymer interaction with tumour cells and tissue is explored using in vitro assays through to preclinical validation.

Keyphrases

cancer therapy
drug delivery
induced apoptosis
cell cycle arrest
high throughput
stem cells
cell death
endoplasmic reticulum stress