First Clinical Results of Fluorescence Lifetime-enhanced Tumor Imaging Using Receptor-targeted Fluorescent Probes.
Rahul PalMarisa E HomNynke S van den BergThinzar M LwinYu-Jin LeeAndrey PrilutskiyWilliam C Faquin Md PhDEric YangSrinivas Vinod SaladiMark A VarvaresEben L RosenthalAnand T N KumarPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Our data indicate that FLT imaging is a promising approach for enhancing tumor contrast using an antibody-targeted NIR probe with a proven safety profile in humans, suggesting a strong potential for clinical applications in image guided surgery, cancer diagnostics, and staging.
Keyphrases
- living cells
- high resolution
- fluorescence imaging
- fluorescent probe
- minimally invasive
- quantum dots
- cancer therapy
- single molecule
- acute myeloid leukemia
- papillary thyroid
- magnetic resonance
- lymph node
- small molecule
- photodynamic therapy
- coronary artery bypass
- electronic health record
- tyrosine kinase
- computed tomography
- squamous cell
- acute coronary syndrome
- coronary artery disease
- human health
- energy transfer
- machine learning
- climate change
- surgical site infection