Noninferiority Trials to Evaluate Drug Effects in Rheumatoid Arthritis.
Rebecca ChiuNikolay P NikolovJanet W MaynardGregory LevinPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
Active-controlled studies in RA with justified NI margins can provide persuasive evidence of treatment effects on symptomatic, functional, and radiographic end points. Such studies can also provide reliable, controlled safety data and relevant information for treatment decisions in clinical practice. Thus, we recommend considering NI designs in future clinical trials in RA.