Antimicrobial Natural Products Produced by Soil-Derived Fungus Penicillium cremeogriseum W1-1.
Xu-Yan SangZhao-Jie WangYa-Bin YangYong-Liang WangMei-Ling XiangDou-Ying ZhuYing ZhouXiao-Dong LuoLi-Xing ZhaoPublished in: Indian journal of microbiology (2021)
Ten compounds (1-10) were obtained from soil-derived Penicillium cremeogriseum W1-1 with the antimicrobial guided isolation procedure. Among them, 4 presented broad-spectrum antimicrobial activities and its preliminary mechanisms were evaluated. Compound 4 showed growth inhibition on drug-resistant pathogenic strains Escherichia coli and Candida albicans with post-contact effect (PCE), changed the morphology and membrane structure, killed cells with leakage, inhibited the growth of C. albicans by eradicating biofilms. Interestingly, the fraction containing 4 presented in vivo anti-pathogenic activities in mice, indicating this indole diterpenoid alkaloid could been used as potential antimicrobial agent.
Keyphrases
- candida albicans
- drug resistant
- staphylococcus aureus
- escherichia coli
- biofilm formation
- multidrug resistant
- induced apoptosis
- acinetobacter baumannii
- oxidative stress
- cell cycle arrest
- skeletal muscle
- cell proliferation
- klebsiella pneumoniae
- metabolic syndrome
- signaling pathway
- adipose tissue
- endoplasmic reticulum stress
- human health