Interferon regulatory factor 1 (IRF-1) downregulates Checkpoint kinase 1 (CHK1) through miR-195 to upregulate apoptosis and PD-L1 expression in Hepatocellular carcinoma (HCC) cells.

Yihe YanLeting ZhengQiang DuXiao CuiKun DongYarong GuoDavid A Geller

Published in: British journal of cancer (2021)

IRF-1 induces miR-195 to suppress CHK1 protein expression. Both increased IRF-1 and decreased CHK1 upregulate cellular apoptosis and PD-L1 expression in HCC.

Keyphrases

cell cycle arrest
dendritic cells
cell proliferation
pi k akt
cell death
endoplasmic reticulum stress
induced apoptosis
long non coding rna
dna damage response
oxidative stress
long noncoding rna
cell cycle
signaling pathway
transcription factor
immune response
protein kinase
dna repair