Systematic review of health related-quality of life in adults with osteogenesis imperfecta.

Darran Mc DonaldTara Mc DonnellJulie Martin-GraceGerry Mc ManusRachel K Crowley

Published in: Orphanet journal of rare diseases (2023)

OI in adulthood has a wide-ranging negative impact on HR-QOL. Physical and respiratory HR-QOL were lower, while the prevalence of pain and fatigue were higher than in reference populations. Mental HR-QOL was relatively preserved, although some deficits were identified. Age and cardio-pulmonary co-morbidities were associated with lower HR-QOL.

Keyphrases

systematic review
mental health
chronic pain
traumatic brain injury
pulmonary hypertension
meta analyses
risk factors
depressive symptoms
pain management
neuropathic pain
respiratory tract