Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects.
Agnieszka KilanowskaAgnieszka ZiółkowskaPublished in: International journal of molecular sciences (2022)
Diabetes mellitus is a heterogeneous disease of complex etiology and pathogenesis. Hyperglycemia leads to many serious complications, but also directly initiates the process of β cell apoptosis. A potential strategy for the preservation of pancreatic β cells in diabetes may be to inhibit the implementation of pro-apoptotic pathways or to enhance the action of pancreatic protective factors. The Hippo signaling pathway is proposed and selected as a target to manipulate the activity of its core proteins in therapy-basic research. MST1 and LATS2, as major upstream signaling kinases of the Hippo pathway, are considered as target candidates for pharmacologically induced tissue regeneration and inhibition of apoptosis. Manipulating the activity of components of the Hippo pathway offers a wide range of possibilities, and thus is a potential tool in the treatment of diabetes and the regeneration of β cells. Therefore, it is important to fully understand the processes involved in apoptosis in diabetic states and completely characterize the role of this pathway in diabetes. Therapy consisting of slowing down or stopping the mechanisms of apoptosis may be an important direction of diabetes treatment in the future.
Keyphrases
- cell cycle arrest
- type diabetes
- cell death
- pi k akt
- glycemic control
- induced apoptosis
- endoplasmic reticulum stress
- signaling pathway
- cardiovascular disease
- oxidative stress
- stem cells
- cell proliferation
- diabetic rats
- primary care
- healthcare
- insulin resistance
- current status
- epithelial mesenchymal transition
- anti inflammatory
- risk factors
- metabolic syndrome
- risk assessment
- cell therapy
- quality improvement
- human health
- adipose tissue
- mesenchymal stem cells
- high glucose