Dissecting the Shared Genetic Architecture of Common Epilepsies With Cortical Brain Morphology.

Naz Karadag Espen HagenAlexey A ShadrinDennis van der MeerKevin S O'ConnellZillur RahmanGleda KutrolliNadine ParkerShahram BahramiVera FominykhKjell HeuserErik TaubøllNils Eiel SteenSrdjan DjurovicAnders M DaleOleksandr FreiOle Andreas AndreassenOlav B Smeland

Published in: Neurology. Genetics (2024)

Our findings show extensive genetic overlap between generalized epilepsies and cortical morphology, indicating a complex genetic relationship with mixed-effect directions. The results suggest that shared genetic influences may contribute to cortical abnormalities in epilepsies.

Keyphrases

genome wide
copy number
dna methylation
gene expression
brain injury