Raltitrexed as a synergistic hyperthermia chemotherapy drug screened in patient-derived colorectal cancer organoids.

Lisi ZengQuanxing LiaoQuanxing ZhaoShengwei JiangXianzi YangHongsheng TangQingjun HeXiansheng YangShuxian FangJinfu HeWeiwen CuiLaiqiang HuangShaohua MaShu-Zhong Cui

Published in: Cancer biology & medicine (2021)

Our results primarily demonstrated the use of patient-derived colorectal cancer organoids as in vitro models to evaluate hyperthermia synergistic chemotherapeutics. We found that hyperthermia enhanced the effect of raltitrexed the most among the common anti-colorectal cancer drugs.

Keyphrases

cancer therapy
squamous cell carcinoma
locally advanced
radiation therapy
drug induced
induced pluripotent stem cells
adverse drug