Autoimmune activation and hypersensitization of the AT1 and ETA receptors contributes to vascular injury in scleroderma renal crisis.

Björn HegnerTobias KretzschmarNan ZhuGunnar KleinauHongfan ZhaoJulian Kamhieh-MilzJulia HilgerRalf SchindlerPatrick ScheererGabriela RiemekastenAurélie PhilippeRusan Catar

Published in: Rheumatology (Oxford, England) (2022)

We provide experimental evidence that agonistic Abs may contribute to SRC. This effect is presumably related to direct receptor stimulation and additional allosteric effects, at least in heterodimeric receptor constellations. Novel therapies targeted at autoimmune hyperactivation of AT1R and ETAR might improve outcomes in severe cases of SRC.

Keyphrases

tyrosine kinase
multiple sclerosis
drug induced
public health
small molecule
systemic sclerosis
early onset
cancer therapy
type diabetes
rheumatoid arthritis
glycemic control