Stereoselective total synthesis and structural revision of the diacetylenic diol natural products strongylodiols H and I.

The stereoselective total synthesis of strongylodiol H and I has been accomplished. The synthetic procedure comprised the stereoselective reduction of a ketone functionality in an ene-yne-one employing CBS as a catalyst and a Cadiot-Chodkiewicz coupling reaction as the key reaction steps. A common aldehyde intermediate has been used for the synthesis of both strongylodiols.