Nanoparticle-cell-nanoparticle communication by stigmergy to enhance poly(I:C) induced apoptosis in cancer cells.
Amelia UltimoCristina de la TorreCristina GiménezElena AznarCarmen CollM Dolores MarcosJosé R MurguíaRamón Martínez-MáñezFélix SancenónPublished in: Chemical communications (Cambridge, England) (2021)
Nanoparticle-cell-nanoparticle communication by stigmergy was demonstrated using two capped nanodevices. The first community of nanoparticles (i.e.S(RA)IFN) is loaded with 9-cis-retinoic acid and capped with interferon-γ, whereas the second community of nanoparticles (i.e.S(sulf)PIC) is loaded with sulforhodamine B and capped with poly(I:C). The uptake of S(RA)IFN by SK-BR-3 breast cancer cells enhanced the expression of TLR3 receptor facilitating the subsequent uptake of S(sulf)PIC and cell killing.
Keyphrases
- induced apoptosis
- single cell
- immune response
- cell therapy
- healthcare
- dendritic cells
- rheumatoid arthritis
- mental health
- drug delivery
- breast cancer cells
- stem cells
- iron oxide
- toll like receptor
- inflammatory response
- signaling pathway
- ankylosing spondylitis
- mesenchymal stem cells
- long non coding rna
- interstitial lung disease
- nuclear factor