Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer's disease neuropathology.

Fading ChenDan B SwartzlanderAnamitra GhoshJohn D FryerBaiping WangHui Zheng

Published in: Molecular neurodegeneration (2021)

We identify Clu as an astrocyte-derived synaptogenic and anti-amyloid factor; the combination of these activities may influence the progression of late-onset AD.

Keyphrases

late onset
early onset
cognitive decline
mouse model
prefrontal cortex
mild cognitive impairment