Comparison among populations with severe and intermediate alpha1-antitrypsin deficiency and chronic obstructive pulmonary disease.

Davide PiloniStefania OttavianiLaura SaderiLuciano CordaPaolo BadernaValentina BarzonAlice M BalderacchiChristine SeebacherBruno BalbiFederica AlbiciniAlessandra CorinoMaria C MennittiClaudio TirelliFabio SpreaficoMatteo BosioFrancesca MarianiGiovanni SotgiuAngelo G CorsicoIlaria Ferrarotti

Published in: Minerva medica (2023)

The comparison of populations with PI*ZZ, MZ and MM genotypes allows to delineate the role of alpha1-antitrypsin deficiency on respiratory function and on the impact on quality of life, in relation to other risk factors. These results highlight the crucial role of primary and secondary prevention on smoking habits in PI*MZ subjects and the importance of an early diagnosis.

Keyphrases

chronic obstructive pulmonary disease
risk factors
lung function
replacement therapy
genetic diversity
air pollution
respiratory tract