Mechano-Redox Control of Macrophage-1 Antigen De-Adhesion From ICAM-1 (Intercellular Adhesion Molecule 1) by Protein Disulfide Isomerase Promotes Directional Movement Under Flow.

Alexander DupuyCamilo Aponte-SantamaríaAdva YeheskelElinor HortleStefan H OehlersFrauke GräterPhilip J Hogg Freda H Passam Joyce Chiu

Published in: Circulation research (2023)

Shear-dependent PDI cleavage of the neutrophil Mac-1 C224-C264 disulfide bond triggers Mac-1 de-adherence from ICAM-1 at the trailing edge of the cell and enables directional movement of neutrophils during inflammation.

Keyphrases

cell adhesion
biofilm formation
oxidative stress
single cell
adipose tissue
cell therapy
cell migration
dna binding
protein protein
amino acid
pseudomonas aeruginosa
small molecule
metabolic syndrome
stem cells
escherichia coli
cystic fibrosis
candida albicans
transcription factor
transition metal