Nucleolar Localization of the RNA Helicase DDX21 Predicts Survival Outcomes in Gynecologic Cancers.

Marwa W Aljardali Kevin M Kremer Jessica E Parker Elaine Fleming Hao Chen Jayanthi S Lea W Lee Kraus Cristel V Camacho

Published in: Cancer research communications (2024)

Currently, there are no reliable biomarkers for response to PARPi outside of homologous recombination deficiency. Herein we present a unique potential biomarker, with clear functional understanding of the molecular mechanism by which DDX21 nucleolar localization can predict response to PARPi.

Keyphrases

dna repair
dna damage
replacement therapy
nucleic acid
smoking cessation