TRIM65 determines the fate of a novel subtype of pituitary neuroendocrine tumors via ubiquitination and degradation of TPIT.

Hong YaoWanqun XieYuting DaiYanting LiuWeiting GuJian-Feng LiLiang WuJing XieWeiwei RuiBohan RenLi XueYijun ChengShaojian LinChangsheng LiHao TangYu WangMeiqing LouXiaobiao ZhangRonggui HuHanbing ShangJinyan HuangZhe Bao Wu

Published in: Neuro-oncology (2022)

Our studies provided a novel classification of PitNETs and revealed that the TRIM65-TPIT complex controlled the fate of the novel subtype of PitNETs, which provides a potential therapy target for Cushing's disease.

Keyphrases

neuroendocrine tumors
machine learning
deep learning
single cell
case control
growth hormone
mesenchymal stem cells
cell therapy
smoking cessation