Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging.
David MatuskeySule TinazKyle C WilcoxMika NaganawaTakuya ToyonagaMark DiasShannan HenryBrian PittmanJim RopchanNabeel NabulsiIvonne SuridjanRobert A ComleyYiyun HuangSjoerd J FinnemaRichard E CarsonPublished in: Annals of neurology (2020)
This work provides the first evidence of synaptic loss in brainstem nuclei involved in the pathogenesis of Parkinson disease in living patients. SV2A imaging holds promise for understanding synaptic changes central to the disease. Ann Neurol 2020;87:329-338.