Relationship Between Genetic Risk and Age of Diagnosis in Systemic Lupus Erythematosus.

Daniela DominguezSylvia KamphuisJoseph BeyeneJoan WitherJohn B HarleyIrene BlancoCatarina Vila-IndaHermine I BrunnerMarissa Klein-GitlemanDeborah McCurdyDawn M WaheziThomas LehmanMarija JelusicChristine A Peschken Janet E PopeDafna D GladmanJohn G HanlyAnn E ClarkeSasha BernatskyChristian PineauC Douglas SmithSusan BarrGilles BoireEric RichEarl D Silvermannull null

Published in: The Journal of rheumatology (2020)

Our data suggest that there is a linear relationship between genetic risk and age of SLE diagnosis and that HLA and non-HLA GRS are associated with age of diagnosis in opposite directions.

Keyphrases

genome wide
systemic lupus erythematosus
copy number
dna methylation
gene expression
disease activity
deep learning
artificial intelligence