HER2 in uterine serous carcinoma: Current state and clinical perspectives.

Janira M Navarro SanchezBrian S FinkelmanBradley M TurnerHani KaterjiXi WangSharlin VargheseTiannan WangYan PengDavid G HicksHuina Zhang

Published in: American journal of clinical pathology (2023)

This review discusses the clinical perspective of HER2 overexpression/gene amplification in USC, the distinct HER2 staining pattern and the evaluation of HER2 in USC, the resistance mechanisms of HER2-targeted therapy in HER2-positive cancers, and likely areas of future investigation.

Keyphrases

copy number
transcription factor
cell proliferation
high grade
current status
young adults
dna methylation