Wushenziye Formula Inhibits Pancreatic β Cell Apoptosis in Type 2 Diabetes Mellitus via MEK-ERK-Caspase-3 Signaling Pathway.

Chunyu Tian Hong ChangXiaojin LaJi-An LiLeilei Ma

Published in: Evidence-based complementary and alternative medicine : eCAM (2018)

These findings indicate that WSZYF may become a new drug candidate in the treatment of T2DM and its antidiabetic mechanism is probably inhibiting pancreatic β cell apoptosis by modulating the MEK-ERK-Caspase-3 signaling pathway.

Keyphrases

signaling pathway
pi k akt
induced apoptosis
cell proliferation
epithelial mesenchymal transition
cell death
emergency department
metabolic syndrome
type diabetes
endoplasmic reticulum stress
preterm infants
combination therapy
adverse drug
human milk
insulin resistance
drug induced
oxidative stress