Higher levels of cerebrospinal fluid and plasma neurofilament light in human immunodeficiency virus-associated distal sensory polyneuropathy.

Ronald J EllisAhmed ChennaYolanda LieDusica CuranovicJohn WinslowBin TangChristina M MarraLeah H RubinDavid B CliffordJ Allen McCutchanBenjamin B GelmanJessica Robinson-PappChristos J PetropoulosScott L Letendre

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)

Both plasma and CSF NFL were elevated in PWH and PWoH with DSP. The convergence of our findings with others demonstrates that NFL is a reliable biomarker reflecting peripheral nerve injury. Biomarkers such as NFL might provide, validate, and optimize clinical trials of neuroregenerative strategies in HIV DSP.

Keyphrases

human immunodeficiency virus
cerebrospinal fluid
peripheral nerve
antiretroviral therapy
hepatitis c virus
hiv infected
clinical trial
hiv positive
hiv aids
minimally invasive
hiv testing
south africa
phase iii
study protocol