B cells establish, but do not maintain, long-lived murine anti-peanut IgE(a).
Daphne M MoutsoglouS C DreskinPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2016)
Peanut allergy can be established in a NA hosts with B220(+) cells from PA donors and CD4(+) cells from peanut-NA donors. However, long-term depletion of B220(+) cells with anti-CD20 antibody does not affect anti-peanut IgE levels. These results highlight a novel role for B cells in the development of PNA and provide evidence that long-lived anti-peanut IgE levels may be maintained by long-lived ASCs.
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