Acetylation Rather than H50Q Mutation Impacts the Kinetics of Cu(II) Binding to α-Synuclein.
Xiangyu TengAlena M ShevelevaFloriana TunaKeith Robert WillisonLiming YingPublished in: Chemphyschem : a European journal of chemical physics and physical chemistry (2021)
The front cover artwork is provided by the group of Liming Ying at Imperial College London. The image shows that N-terminal acetylation of α-synuclein shifts the binding from the N-terminus to His50 and significantly slows down the binding reaction. Read the full text of the Article at 10.1002/cphc.202100651.