Proversilins A-E, Drimane-Type Sesquiterpenoids from the Endophytic Aspergillus versicolor.
Huaqiang LiRunge ZhangFei CaoJianping WangZheng-Xi HuYong-Hui ZhangPublished in: Journal of natural products (2020)
Five new drimane-type sesquiterpenoids, named proversilins A-E (1-5), were isolated from the endophytic fungus Aspergillus versicolor F210 isolated from the bulbs of Lycoris radiata. Their structures and absolute configurations were characterized by extensive spectroscopic analysis, including 1D and 2D NMR and HRESIMS data, comparison of experimental and calculated electronic circular dichroism data, and X-ray crystallography. Proversilins B-E (2-5) represent the first examples of natural products featuring an N-acetyl-β-phenylalanine moiety. Compounds 3 and 5 inhibited the growth of HL-60 cells with IC50 values of 7.3 and 9.9 μM, respectively.
Keyphrases
- high resolution
- electronic health record
- induced apoptosis
- big data
- magnetic resonance
- cell cycle arrest
- molecular docking
- cell wall
- data analysis
- computed tomography
- magnetic resonance imaging
- signaling pathway
- endoplasmic reticulum stress
- cell proliferation
- cell death
- dual energy
- mass spectrometry
- artificial intelligence
- contrast enhanced