Proton FLASH: Impact of Dose Rate and Split Dose on Acute Skin Toxicity in a Murine Model.

Brita Singers SørensenEleni KanoutaChristina AnkjærgaardLine KristensenJacob G JohansenMateusz Krzysztof SitarzClaus E AndersenCai GrauPer Poulsen

Published in: International journal of radiation oncology, biology, physics (2024)

The dose rate that induced a FLASH effect varied for different skin toxicity levels, which are characterized by a differing degree of sensitivity to radiation dosage. Conclusions on a threshold for the dose rate needed to obtain a FLASH effect can therefore be influenced by the dose sensitivity of the used endpoint. Splitting the total dose into more deliveries compromised the FLASH effect. This can have an impact for fractionation as well as for regions where 2 or more FLASH fields overlap within the same treatment session.

Keyphrases

liver failure
radiation therapy
intensive care unit
high intensity
wound healing
soft tissue
acute respiratory distress syndrome