The association of ABCB1 gene polymorphism with clinical response to carbamazepine monotherapy in patients with epilepsy.
Haroon Ur RashidShakir UllahDaniel F CarrMuhammad Ijaz Khan KhattakMuhammad Imran AsadMujeeb Ur RehmanMuhammad Khalid TipuPublished in: Molecular biology reports (2024)
Our results showed that variant alleles of the ABCB1 gene and TTT, TTC haplotypes were significantly associated with CBZ resistance without affecting the plasma level of carbamazepine. The findings of this study may help to predict patient's response to treatment ultimately it will improve the personalized and evidence based treatment choice of patients with epilepsy.