Dexmedetomidine promotes colorectal cancer progression via Piwil2 signaling.

Jing DongJi CheYuanyuan WuYixu DengXuliang JiangZhiyong HeJun Zhang

Published in: Cellular oncology (Dordrecht) (2024)

DEX promotes CRC progression may via activating α2 adrenoceptor-dependent Nrf2/Piwil2/Siah2 pathway and thus EMT process. Our work provides a novel insight into the mechanism underlying tumor-promoting effects of α2-adrenoceptor agonists.

Keyphrases

epithelial mesenchymal transition
oxidative stress
signaling pathway
acute kidney injury