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Concise synthesis of α-cyano tetrahydroisoquinolines with a quaternary center via Strecker reaction.

Yue JiXue ZhangWeiwei HanSichang WangYa WuKeliang ZhangPenghui YangPei XiaoYitao Wei
Published in: RSC advances (2021)
A concise synthesis of α-cyano tetrahydroisoquinolines with a quaternary center via the Strecker reaction was successfully realized by employing TMSCN as cyano source and KF as fluoride source, furnishing the products with up to 99% yield. An isomerization of α-cyano tetrahydroisoquinoline was observed under alkaline conditions to give the isomer via [1,3]-H shift.
Keyphrases
  • drinking water