USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages.
Maija RuuthJarkko SoronenEssi KaiharjuKrista MerikantoJulia PerttiläJari MetsoMiriam Lee-RueckertMarja-Riitta TaskinenPetri T KovanenKatariina ÖörniVesa M OlkkonenMatti S JauhiainenPirkka-Pekka LaurilaPublished in: Lipids in health and disease (2018)
Our findings identify USF1 as a novel factor regulating HDL functionality, showing that USF1 inactivation boosts cholesterol efflux, reduces macrophage inflammation and attenuates macrophage cholesterol accumulation, linking improved macrophage cholesterol metabolism and inflammatory pathways to the antiatherogenic function of USF1 deficiency.