Eating while intoxicated: characterizing the molecular mechanism behind V. cholerae toxin MakA-regulated autophagy.
Dale P CorkeryYao-Wen WuPublished in: Autophagy (2022)
Extracellular pathogens utilize secreted virulence factors to regulate host cell function. Recently we characterized the molecular mechanism behind host macroautophagy/autophagy regulation by the Vibrio cholerae toxin MakA. Cholesterol binding at the plasma membrane induces MakA endocytosis and pH-dependent pore assembly. Membrane perforation of late endosomal membranes induces cellular membrane repair pathways and V-ATPase-dependent unconventional LC3 lipidation on damaged membranes.
Keyphrases
- escherichia coli
- cell death
- endoplasmic reticulum stress
- antimicrobial resistance
- signaling pathway
- oxidative stress
- pseudomonas aeruginosa
- staphylococcus aureus
- physical activity
- biofilm formation
- transcription factor
- weight loss
- mass spectrometry
- simultaneous determination
- low density lipoprotein
- binding protein
- liquid chromatography
- multidrug resistant