Effects of resveratrol on the proliferation and osteogenic differentiation of deciduous dental pulp stem cells from neurofibromatosis type 1 patient.

Claudinéia Pereira MarandubaGustavo Torres SouzaAntônio Márcio Resende do CarmoJosé Marcelo Sallabert de CamposNádia Rezende Barbosa RaposoMarcelo de Olivera SantosCarlos Magno da Costa MarandubaFernando de Sá Silva

Published in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (2020)

In conclusion, in a dose-dependent manner, resveratrol displays interesting properties that could be applied in a possible treatment aimed at decreasing cellular proliferation in neurofibromatosis. Furthermore, it is selective concerning healthy cells and not affecting cell differentiation. Further research to cell selectivity, differentiation to other tissue types, and cell cytotoxicity are needed.

Keyphrases

single cell
signaling pathway
cell therapy
induced apoptosis
cell cycle arrest
bone marrow
cell death
combination therapy
structural basis