Enhanced local and systemic inflammatory cytokine mRNA expression in women with endometriosis evokes compensatory adaptive regulatory mRNA response that mediates immune suppression and impairs cytotoxicity.

Emma BjörkMarie-Therese VinnarsIvan NagaevOlga NagaevaEva LundinUlrika OttanderLucia Mincheva-Nilsson

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2020)

The ectopic implantation seen in endometriosis could be possible as a consequence of increased inflammation and priming of adaptive T regulatory cells, resulting in impaired cytotoxicity and enhanced immune suppression.

Keyphrases

oxidative stress
induced apoptosis
transcription factor
cell cycle arrest
signaling pathway
binding protein